Structure Of A Nucleosome-bound Muvb Transcription Issue Complex Reveals Dna Remodelling Nature Communications

Structure and dynamics of a 197 bp nucleosome in complicated with linker histone H1. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complicated represses human cell cycle-dependent genes in quiescence. On the other side, ~10 base pairs of the exit DNA at SHL +7 are not visible in our complex (Fig.4f), indicating that this stretch of DNA is disordered. Interestingly, the unwrapping at SHL +7 is also observed in structures of…Read More